1992
De La Salle University establishes the Bienvenido N. Santos Distinguished Professorial Chair in Creative Writing and the Bienvenido N. Santos Creative Writing Center.
 
1990
Doctor of Arts in Language and Literature, honoris causa, De La Salle University, Manila
 
1987
Southeast Asia Write Award, Bangkok, Thailand
 
1987
Manila Critic Circle National Book Award for Fiction, for What the Hell for You Left Your Heart in San Francisco
 
1983
Doctor of Philosophy and Letters, honoris causa, University of Nueva Caceres, Naga City
 
1983
Manila Critics Circle National Book Award for Fiction, for The Praying Man
 
1982
Doctor of Philosophy in Humane Letters, honoris causa, Wichita State University, Wichita, Kansas
 
1982
"X" Award, Book Development Association of the Philippines, for The Praying Man.
 
1981
National Endowment for the Arts Award in Fiction, Washington, D.C.
 
1981
Doctor of Letters and Humanities, honoris causa, University of the Philippines, Manila; Doctor of Philosophy in Literature, honoris causa, Bicol University, Legazpi City.
 
1981
American Book Award by the Before Columbus Foundation of Berkeley, California, for Scent of Apples.
 
1977
New Letters (University of Missouri, Kansas City) Prize for Fiction for "Immigration Blues."
 
1973
Appointed Distinguished Writer-in-Residence, Wichita State University.
 
1971
Medallion of Honor for Distinguished Writer and Educator, on the 400th Anniversary of the Founding of the City of Manila.
 
1965
Republic Cultural Heritage Award, by the Philipine Government, Manila; Fulbright Exchange Professorship to the University of Iowa.
 
1960
University of Iowa Literary Foundation Award; John Simon Guggenheim Memorial Foundation Fellowship in Creative Writing.
 
1958-60
Rockefeller Fellowship to the Writers Workshop, University of Iowa.
 
1957
First Prize, Philippines Free Press Short Story Contest for "Brother, My Brother."
 
1956
Second Prize, Carlos Palanca Memorial Awards for Literature, Short Story Category, for "The Transfer."
 
1950
First Prize, World Short Story Contest, New York Herald Tribune, Paris edition, for "The Naked Eye."